SLC Enteric NMN 200ct (Nicotinamide Mononucleotide, Delayed Release) 250mg

USD 69.95

Description

NAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. SLC NMN helps boost NAD+ production by providing NMN, a direct precursor to NAD+.† "Together, this highlights that a multi-target strategy for NAD+ restoration such as the use of a precursor in combination with inhibitors and/or activators acting at other key points in the NAD+ network may be the optimum approach to NAD+ restoration." (1) Nicotinamide mononucleotide (NMN) is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for: Energy production† DNA repair† Regulation of genes† Cellular health and vitality† Immune function† Regulation of the sleep-wake cycle† NAD+ levels naturally decline with age, which research suggests is linked to the onset and progression of age-related diseases.† This makes increasing NAD+ levels a promising therapeutic target.† NMN serves as a direct precursor to NAD+, acting as a potent booster to elevate your NAD+ levels.† SLC NMN is designed for enhanced absorption by promoting its interaction with the NMN transporter, Slc12a8.† The NMN Transporter – Slc12a8 A 2019 study found some NMN can be transported directly through the cell membrane by the Slc12a8 Transporter and converted to NAD+ inside the small intestine. The results from their study showed that older mice had increased levels of the transporter, leading to greater increases in NAD+ levels after NMN supplementation compared to young mice. “​​Therefore, increasing NMN availability or stimulating the function of the NMN transporter could effectively counteract age-associated NAD+ decline in the aged small intestine.” Protecting NMN from Digestion by Bacteria is Key However, another study showed that most NMN is degraded by bacteria in your gut, limiting the amount of NAD+ that can be produced from standard NMN formulations. These figures show the effect of gut bacteria on the intestinal levels of NMN (on the left) and NAD+ (on the right) after NMN supplementation. Gray bar: Normal, untreated mice Yellow bar: Mice receiving antibiotics Blue bar: Mice receiving NMN Red bar: Mice receiving antibiotics and NMN The yellow and red bars represent mice given antibiotics to deplete their gut bacteria. Their levels are many times higher than mice with normal gut bacteria. SLC NMN SLC NMN uses a specially designed capsule that safeguards NMN from degradation by gut bacteria, ensuring that it arrives intact at the Slc12a8 transporter in your gut.† This unique NMN formulation features a number of key advantages to enhances absorption through Slc12a8 and promote your overall well-being: Acid-resistant capsules: SLC NMN capsules are designed to protect the NMN through the stomach, providing more intact NMN in the small intestine for uptake by SLC12a8† Trimethylglycine (TMG): TMG is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity† Immune support: SLC NMN includes zinc, which is an important nutrient for immune function† Sodium Bicarbonate: Sodium ions are needed for Slc12a8 to work properly, so we include them in our capsules along with NMN. This helps to ensure that more NMN is absorbed into your cells† Enteric (Acid-Resistant) Capsules HOW IT WORKS SAFEGUARDING FROM DIGESTION Enteric CAPS VS LIPOSOMAL How It Works The enteric coated (acid-resistant) capsules are specifically designed to protect ingredients from the harsh acidic stomach, while safeguarding them from being degraded and digested by bacteria and enzymes. The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract - with NAD+ precursors being particularly vulnerable to this. The enteric (acid-resistant) capsules safeguard the ingredients to support better absorption, and a slower release into the bloodstream. Research shows that NAD+ precursors are largely degraded and digested by enzymes and bacteria in the stomach, to other metabolites that are less effective. (1) NMN Degraded By Bacteria in the Stomach This chart shows a significant elevation in NMN levels after antibiotic administration. This can be attributed to the antiobiotic's impact on stomach bacteria, which causes a reduction in overall diversity. NR Degraded By Bacteria in the Stomach This study reveals a substantial breakdown of NR into various metabolites (NAM, NA, NAR) within the colon. The blue bars represent orally administered NR. In mice without gut bacteria (GF NR), almost none of the NR is converted into the metabolites mentioned. This suggests that gut bacteria plays a significant role in the breakdown of NR in the digestive system. Delivery Systems to Improve Absorption Several delivery systems have been developed to protect NAD+ and precursors from being broken down and to enhance their absorption. In other products, we use advanced Liposomal technology which protect NAD+, NMN, and NR from degradation in the GI tract and liver, but this delivery system adds significant cost. We are committed to providing diverse and effective delivery methods that cater to various budgets and preferences. We believe that enteric (acid-resistant) capsules are superior to the standard capsules sold online, offering improved absorption at a lower cost than our competitors.